Wednesday, April 22, 2009
All Times Eastern
| Away | Home | Time (ET) | Away Probable | Home Probable | MLB.TV | Tickets |
| Marlins | Pirates | 12:35 p.m. | Nolasco (1-1) | Maholm (2-0) |  | Buy  |
| Twins | Red Sox | GM 1: 12:35 p.m. | Baker (0-1) | Wakefield (1-1) | | Buy |
| Athletics | Yankees | 1:05 p.m. | Anderson (0-2) | Sabathia (1-1) | | Buy |
| Rockies | D-Backs | 3:40 p.m. | De La Rosa (0-1) | Haren (0-3) | | Buy |
| Padres | Giants | 3:45 p.m. | Young (2-0) | Zito (0-2) | | Buy |
| Braves | Nationals | 7:05 p.m. | Jurrjens (2-1) | Lannan (0-2) | | Buy |
| White Sox | Orioles | 7:05 p.m. | Danks (1-0) | Guthrie (2-0) | | Buy |
| Royals | Indians | 7:05 p.m. | Bannister (0-0) | Lee (1-2) | | Buy |
| Brewers | Phillies | 7:05 p.m. | Looper (1-0) | Blanton (0-1) | | Buy |
| Rangers | Blue Jays | 7:07 p.m. | Harrison (0-2) | Purcey (0-1) | | Buy |
| Twins | Red Sox | GM 2: 7:10 p.m. | Liriano (0-3) | Penny (1-0) | | Buy |
| Reds | Cubs | 8:05 p.m. | Cueto (0-1) | Lilly (2-0) | | Buy |
| Dodgers | Astros | 8:05 p.m. | Wolf (1-1) | Oswalt (0-2) | | Buy |
| Mets | Cardinals | 8:15 p.m. | Maine (0-1) | Pineiro (2-0) | | Buy |
| Tigers | Angels | 10:05 p.m. | Verlander (0-2) | Saunders (2-1) | | Buy |
| Rays | Mariners | 10:10 p.m. | Niemann (0-2) | Jakubauskas (1-1) | | Buy |
